Title:
ISOTHIAZOLYL COMPOUND, ITS MANUFACTURE AND MEDICINE CONTAINING IT
Document Type and Number:
Japanese Patent JPS56142290
Kind Code:
A
Abstract:
7 beta -Aminoisothiazolylacetamido-3-cephem-4-carboxylic acid compounds of the formula in which n is 0 or 1, Am is an optionally protected amino group, A is a group -CH2-, -C(=O)- or -C(=N-O-R1)-, in which R1 is hydrogen, optionally substituted lower alkyl or cycloalkyl, or optionally N-substituted carbamoyl, R2 is hydrogen or lower alkoxy, R3 is hydrogen, etherified or esterified hydroxyl, etherified mercapto, formyl or the radical of the formula -CH2-R@ in which R@ is hydrogen, hydroxyl, acyloxy, heterocyclylthio or ammonio, and R4 is an optionally protected carboxyl group, and salts of these compounds which have a salt-forming group, have antibiotic properties against gram-positive and gram-negative microorganisms. Intermediates and starting materials are also described.
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Inventors:
BIITO MIYUURAA
Application Number:
JP3512681A
Publication Date:
November 06, 1981
Filing Date:
March 11, 1981
Export Citation:
Assignee:
CIBA GEIGY AG
International Classes:
A61K31/545; A61K31/546; A61P31/04; C07D275/03; C07D501/20; C07D501/24; C07D501/34; C07D501/36; C07D501/46; C07D501/57; C07D501/59; C07D275/02; (IPC1-7): A61K31/545; C07D501/22; C07D501/24; C07D501/34; C07D501/36; C07D501/46; C07D501/57; C07D501/59