Title:
同位体標識した化学的に安定な試薬およびその合成方法
Document Type and Number:
Japanese Patent JP5204401
Kind Code:
B2
Abstract:
A radioisotope labeled reagent includes a compound having the general formula (I), L-(aCbH2)naCbH3 (I) where a in each occurrence independently is a carbon mass number between 11 and 14 inclusive, b in each occurrence independently is a hydrogen mass number between 1 and 3 inclusive, such that a in each occurrence is not 12 simultaneously with b in each occurrence being 1; L is a leaving group R1SO2—O—, R1—S—, 12C1H3(12C1H2)n—S—R1C(O)O—, NC—, (R1)3P—, XMg- and Li—, where n is an integer between 0 and 3 inclusive, where X is chloro, bromo or iodine, where R1 is H, aryl, a substituent containing aryl, C1-C20 alkyl, a substituent containing C1-C20 alkyl, C2-C20 alkenyl, a substitute containing C2-C20 alkenyl, C2-C20 alkynyl, and a substitute containing C2-C20 alkynyl with the proviso that when n is 0, a is 13 and b is 2 and R1 in R1—S is not aryl.
Inventors:
Pounds Jerry Scott
Application Number:
JP2006515007A
Publication Date:
June 05, 2013
Filing Date:
May 28, 2004
Export Citation:
Assignee:
PERKINELMER HEALTH SCIENCES, INC.
International Classes:
A61K51/00; C07C309/30; C07B59/00; C07C67/10; C07C303/26; C07C303/30; C07C309/40; C07C309/63; C07D207/04; C07D207/09; C07D211/66; C07D453/02; C07D471/04; C07C309/73; C07C
Domestic Patent References:
| JP2001502344A | ||||
| JP8208555A | ||||
| JP5294922A | ||||
| JP4225990A | ||||
| JP56123938A | ||||
| JP56500538A |
Foreign References:
| WO1999012902A1 |
Other References:
Journal of the Chemical Society, Perkin Transactions 2,1991年,(11),p.1741-1746
Organometallics,1985年,4(8),p.1376-1386
Journal of the Chemical Society, Perkin Transactions 1,1984年,(12),p.2919-2925
Journal of Labelled Compounds and Radiopharmaceuticals,1982年,19(5),p.631-637
Chemische Berichte,1981年,114(10),p.3253-3272
Synthetic Communications,1995年,25(17),p.2685-2693
Chemical Physics Letters,1985年,122(5),p.442-446
Journal of Neurochemistry,1984年,43(6),p.1515-1521
Journal of Labelled Compounds and Radiopharmaceuticals,1980年,17(5),p.613-626
Acta Chemica Scandinavica,1966年,20(3),p.908-910
Organometallics,1985年,4(8),p.1376-1386
Journal of the Chemical Society, Perkin Transactions 1,1984年,(12),p.2919-2925
Journal of Labelled Compounds and Radiopharmaceuticals,1982年,19(5),p.631-637
Chemische Berichte,1981年,114(10),p.3253-3272
Synthetic Communications,1995年,25(17),p.2685-2693
Chemical Physics Letters,1985年,122(5),p.442-446
Journal of Neurochemistry,1984年,43(6),p.1515-1521
Journal of Labelled Compounds and Radiopharmaceuticals,1980年,17(5),p.613-626
Acta Chemica Scandinavica,1966年,20(3),p.908-910
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama