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Title:
ISOTOPE PREPARATION METHOD
Document Type and Number:
Japanese Patent JP2016156839
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide methods of the commercial-scale production of radium-223 having a purity acceptable for pharmaceutical administration to human subjects.SOLUTION: The present invention provides a method for the generation ofRa of pharmaceutically tolerable purity, comprising the steps of: i) preparing a generator mixture comprisingAc,Th andRa; ii) loading the generator mixture onto a strong base anion exchange resin; iii) eluting theRa from the strong base anion exchange resin using a first mineral acid in an alcoholic aqueous solution to give a first elutedRa solution; iv) loading theRa of the first elutedRa solution onto a strong acid cation exchange resin; and v) eluting theRa from the strong acid cation exchange resin using a second mineral acid in aqueous solution to provide a second eluted solution. The invention additionally provides products of corresponding purity and/or products obtained or obtainable by such a method.SELECTED DRAWING: Figure 2

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Inventors:
JAN ROGER KARLSON
PEER BORRETZEN
Application Number:
JP2016103089A
Publication Date:
September 01, 2016
Filing Date:
May 24, 2016
Export Citation:
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Assignee:
BAYER AS
International Classes:
G21G4/08; B01J39/04; B01J39/20; B01J41/04; B01J41/14; B01J47/02; B01J49/00
Domestic Patent References:
JP2006523664A2006-10-19
Foreign References:
US6635234B12003-10-21
US6635234B12003-10-21
US5809394A1998-09-15
Other References:
G.HENRIKSEN ET AL.: "２２３Ra for endoradiotherapeutic applications prepared from an immobilized 227Ac/227Th source", RADIOCHIM. ACTA, vol. 89, no. 10, JPN6017018300, 23 March 2001 (2001-03-23), DE, pages 661 - 666, XP009180580, DOI: doi:10.1524/ract.2001.89.10.661
G.HENRIKSEN ET AL.: "２２３Ra for endoradiotherapeutic applications prepared from an immobilized 227Ac/227Th source", RADIOCHIM. ACTA, vol. 89, no. 10, JPN6017018300, 23 March 2001 (2001-03-23), DE, pages 661 - 666, XP009180580, DOI: doi:10.1524/ract.2001.89.10.661
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe



 
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