Title:
ヒストンデアセチラーゼ６阻害剤としてのイソオキサゾールヒドロキサム酸
Document Type and Number:
Japanese Patent JP7455318
Kind Code:
B2
Abstract:
The present disclosure provides compounds represented by Formula (I): and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.
Inventors:
Villagra, Alejandro
Kozikowski, Alan Peay.
shen fern
Kozikowski, Alan Peay.
shen fern
Application Number:
JP2019553370A
Publication Date:
March 26, 2024
Filing Date:
March 29, 2018
Export Citation:
Assignee:
THE GEORGE WASHINGTONUNIVERSITY
International Classes:
C07D261/18; A61K31/42; A61K31/422; A61K31/427; A61K31/437; A61K31/4439; A61K31/4709; A61K31/4725; A61K31/473; A61K31/55; A61K45/00; A61P25/00; A61P35/00; A61P37/02; C07D413/06; C07D413/12; C07D417/06; C07D417/12; C07D471/04
Foreign References:
| US20150344466 | ||||
| WO2017040564A1 |
Other References:
QVORTRUP, K. et al.,Angewandte Chemie, International Edition,2016年,Vol. 55,pp. 4472-4475
GAISINA, I. N. et al.,ChemMedChem,2016年,Vol. 11,pp. 81-92
CONTI, P. et al.,European Journal of Medicinal Chemistry ,2010年,Vol. 45,pp. 4331-4338
TAPADAR, S. et al.,Bioorganic & Medicinal Chemistry Letters,2009年,Vol. 19,pp. 3023-3026
GAISINA, I. N. et al.,ChemMedChem,2016年,Vol. 11,pp. 81-92
CONTI, P. et al.,European Journal of Medicinal Chemistry ,2010年,Vol. 45,pp. 4331-4338
TAPADAR, S. et al.,Bioorganic & Medicinal Chemistry Letters,2009年,Vol. 19,pp. 3023-3026
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Natsuki Morishita