Title:
経粘膜薬物送達システム
Document Type and Number:
Japanese Patent JP2006518761
Kind Code:
A
Abstract:
Disclosed are preparations and formulations of high thermodynamic activity lipophilic associations (LA), in which there is pairing between an ionizable pharmaceutical agent and a lipophilic species having ionic characteristics opposite to that of the pharmaceutical agent. Such lipophilic associations manifest high thermodynamic activity, as evidenced by their being predominantly in a liquid phase at room temperature or solvated in a lower-than-water dielectric solvent. Further the pharmaceutical agent being solubilized means that dissolution is not rate limiting to transmucosal absorption. This LA or LA-solvate is formulated into a low dielectric dosage form, from whence, upon the dosage form's hydration, the pharmaceutical agent is driven through the mucosal tissue and into systemic circulation. The invention therefore provides an enhanced transmucosal drug delivery system for ionizable pharmaceutical agents at or near physiological pH.
Inventors:
McCarty, John A.
Application Number:
JP2006503842A
Publication Date:
August 17, 2006
Filing Date:
February 24, 2004
Export Citation:
Assignee:
Pharmaceutical Productions, Inc.
International Classes:
A61K47/48; A61K9/00; A61K9/14; A61K9/20; A61K31/137; A61K31/4468; A61K31/465; A61K31/5513; A61K31/663; A61K47/02; A61K47/04; A61K47/06; A61K47/10; A61K47/12; A61K47/14; A61K47/18; A61K47/20; A61K47/24; A61K47/34; A61K47/36; A61K47/38; A61K47/44; A61P11/06; A61P19/08; A61P19/10; A61P25/08; A61P25/22; A61P25/32; A61P25/34; A61P29/00; A61P37/08
Domestic Patent References:
| JP2001508027A | 2001-06-19 | |||
| JP2001517624A | 2001-10-09 | |||
| JP2001521882A | 2001-11-13 | |||
| JPS62116507A | 1987-05-28 | |||
| JPH08277216A | 1996-10-22 | |||
| JP2000512295A | 2000-09-19 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita