Title:
神経変性疾患のための潜在的薬物分子の同定における、アミロイドベータタンパク質チャネルその、構造および使用
Document Type and Number:
Japanese Patent JP2008544252
Kind Code:
A
Abstract:
The present invention relates to a novel channel structure of human amyloid beta protein (AbP) in lipid membranes and a rapid, quantitative and specific assay for screening test compounds, such as drugs, ligands (natural or synthetic), proteins, peptides and small organic molecules for their ability to bind and block the membrane AbP channels. The invention further relates to screening and identifying therapeutically relevant compounds for treating Alzheimer's disease and other disorders.
Inventors:
Ral, Ratnes
Quist, argent
Chin, Seungho
Phosphorus, high
Quist, argent
Chin, Seungho
Phosphorus, high
Application Number:
JP2008516947A
Publication Date:
December 04, 2008
Filing Date:
June 09, 2006
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
G01N33/50; G01N33/15; C07K14/47; C07K17/14
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita