五塩化リンとDMFからの副生成物としてのオキシ塩化リンの生成及びビルスマイヤー・ハック試薬への変換による塩素化反応のためのその使用

Title:

五塩化リンとDMFからの副生成物としてのオキシ塩化リンの生成及びビルスマイヤー・ハック試薬への変換による塩素化反応のためのその使用

Document Type and Number:

Japanese Patent JP2008542199

Kind Code:

A

Abstract:

A process is described wherein after formation of first crop of Vilsmeier-Haack reagent by reacting Phosphorus Pentachloride with N,N-dimethylformamide to form a first crop of Vilsmeier reagent as insoluble crystals, a by-product of this reaction, the Phosphorus Oxy-Chloride, reacts with N,N-dimethylformamide to give a second crop of Vilsmeier reagent. This second crop of Vilsmeier reagent is soluble in DMF. This process makes it possible to double the yield of chlorinated substrate, such as sucrose-6-acetate or sucrose-6-benzoate, from the same quantity of Phosphorus Pentachloride.

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Inventors:

Ratnam Rakesh
Sandeep aurora
Mofizuddin Mohammed

Application Number:

JP2008509577A

Publication Date:

November 27, 2008

Filing Date:

April 28, 2006

Export Citation:

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Assignee:

Farmed Medicare Private Limited

International Classes:

C07C249/02; C07B39/00; C07C251/30; C07F9/09; C07H5/02

Attorney, Agent or Firm:

Junichi Omori
Ori Akira

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