To provide a joint cream comprising a combination of medicines selected for reducing the side effects of conventional oral medicines and injections, enhancing simplicity and effectiveness as external remedies, utilizing an action mechanism different from those of conventional anti-inflammatory medicines, enhancing the percutaneous absorption of a medicine in a diseased site (joint cavity), and enhancing a medicine-reaching degree.

This joint cream used for arthritis or arthralgia is characterized by comprising a methylsulfonylmethane (MSM) as a main ingredient, a red pepper extract (capsaicin), and γ-linolenic acid in constant concentrations in a cream base agent. The red pepper extract (capsaicin) is used as an absorption-promoting agent for enhancing the percutaneous absorption of the methylsulfonylmethane to efficiently make the methylsulfonylmethane to reach a joint cavity. The γ-linolenic acid is a cell membrane ingredient having a methylsulfonylmethane percutaneous absorption-promoting effect and a skin moisture-retaining effect.