Title:
KAPPA OPIOID RECEPTOR LIGAND
Document Type and Number:
Japanese Patent JP2009286807
Kind Code:
A
Abstract:
To provide a compound binding with high affinity to kappa opioid receptors.
The invention relates to kappa opioid receptor antagonists that yield significant improvement in functional binding assays to kappa opioid receptors relative to nor-BNI, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
Inventors:
CARROLL F IVY
THOMAS JAMES B
MASCARELLA S WAYNE
THOMAS JAMES B
MASCARELLA S WAYNE
Application Number:
JP2009213451A
Publication Date:
December 10, 2009
Filing Date:
September 15, 2009
Export Citation:
Assignee:
RES TRIANGLE INST
International Classes:
A61K31/4725; C07D211/22; A61K31/445; A61P1/12; A61P3/04; A61P7/12; A61P9/12; A61P11/14; A61P13/02; A61P19/02; A61P25/02; A61P25/04; A61P25/06; A61P25/08; A61P25/16; A61P25/18; A61P25/24; A61P25/26; A61P25/30; A61P25/32; A61P25/34; A61P25/36; A61P31/12; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D401/12
Domestic Patent References:
| JP4511115B2 | 2010-07-28 |
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro