Title:
KETONE DERIVATIVE
Document Type and Number:
Japanese Patent JP3190431
Kind Code:
B2
Abstract:
PURPOSE: To provide a new ketone derivative having high inhibitory activity on thiol protease, also excellent in peroral absorbability, intertissue migration capability and permeability through cell membrane.
CONSTITUTION: The objective compound of formula I [R1 is H or formulas II to V (R10 is alkyl, aryl or heterocyclic residue); R2, R4 and R6 are each H or alkyl; R3 and R5 are each H, aralkyloxy, aryl, alkyl, etc.; R2 and R3 and R4 and R5 are respectively combined into N-contg. heterocycles; R7 is H, alkyl, aralkyloxy, aryl or alkoxy; R8 is H, alkyl or aralkyl; R7 and R8 are combined into benzylidene or cycloalkyl; A is S, SO, SO2, O or NR11 (R11 is H or alkyl); R9 is aryl or (CH2)m-X (X is H, OH, amino, halogen, aryl, etc.; m is 0-15) when A is other than 0, being H or (CH2)1-X (l is 1-15) when A is 0; n is 0 or 1], e.g. (S)-3-[(S)-2-amino-4-methylvalerylamino]-1-furfurylthio-2-heptanone.
Inventors:
Ryoichi Ando
Naoko Ando
Hirokazu Masuda
Yasuhiro Morinaka
Chizuko Takahashi
Yoshikuni Tamao
Akihiro Tobe
Naoko Ando
Hirokazu Masuda
Yasuhiro Morinaka
Chizuko Takahashi
Yoshikuni Tamao
Akihiro Tobe
Application Number:
JP16509492A
Publication Date:
July 23, 2001
Filing Date:
June 23, 1992
Export Citation:
Assignee:
Mitsubishi Chemical Corporation
International Classes:
A61K31/16; A61K31/18; A61K31/27; A61K31/34; A61K31/341; A61K31/35; A61K31/351; A61K31/352; A61K31/36; A61K31/38; A61K31/381; A61K31/40; A61K31/415; A61K31/4184; A61K31/42; A61K31/421; A61K31/425; A61K31/426; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/443; A61K31/4433; A61K31/47; A61K31/472; A61K38/00; A61K38/55; A61P1/16; A61P3/00; A61P7/02; A61P9/00; A61P9/08; A61P9/10; A61P19/10; A61P25/02; A61P25/28; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C07C233/78; C07C237/22; C07C271/20; C07C271/22; C07C311/06; C07C311/19; C07C317/24; C07C317/28; C07C323/22; C07C323/24; C07C323/41; C07C323/59; C07D207/333; C07D213/30; C07D213/32; C07D217/06; C07D235/06; C07D261/08; C07D263/20; C07D263/32; C07D277/22; C07D277/24; C07D277/26; C07D295/10; C07D295/13; C07D307/12; C07D307/38; C07D307/42; C07D307/52; C07D307/54; C07D307/56; C07D307/68; C07D307/84; C07D309/06; C07D311/22; C07D333/24; C07D333/28; C07D333/38; C07D333/60; C07D405/12; C07D407/12; C07D407/14; C07D409/12; C07D409/14; C07K5/06; C07K14/81; (IPC1-7): C07C237/22; A61K31/16; A61K31/18; A61K31/27; A61K31/34; A61K31/35; A61K31/36; A61K31/38; A61K31/40; A61K31/415; A61K31/42; A61K31/425; A61K31/44; A61K31/47; A61K38/00; A61K38/55; C07C233/78; C07C271/20; C07C317/24; C07C323/22; C07C323/24; C07D207/333; C07D213/30; C07D213/32; C07D217/06; C07D235/06; C07D261/08; C07D263/20; C07D263/32; C07D277/22; C07D277/24; C07D295/10; C07D307/12; C07D307/42; C07D307/54; C07D307/68; C07D309/06; C07D311/22; C07D333/24; C07D333/38; C07D333/60; C07D405/12; C07D407/14; C07D409/12; C07D409/14; C07K5/06
Domestic Patent References:
| JP242048A |
Other References:
【文献】米国特許4997950(US,A)
【文献】米国特許5223486(US,A)
【文献】独国特許出願公開294176(DE,A5)
【文献】米国特許5223486(US,A)
【文献】独国特許出願公開294176(DE,A5)
Attorney, Agent or Firm:
Yama directly (2 people outside)