エクジソンレセプター複合体を介した外来遺伝子の発現を調節するためのケトンリガンド

Japanese Patent JP4557717

B2

This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The ligands comprise a class of ketones.

Tice, Colin M
Michelotti, Enrique El
Robert E. Homann

JP2004519931A

October 06, 2010

July 05, 2003

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Intrexon Corporation

C12N15/09; A61K31/166; A61K31/343; A61K31/351; A61K31/357; A61K31/36; A61K31/382; A61K31/44; A61K31/4409; A61K31/445; A61K31/4468; A61K31/519; A61K48/00; A61P43/00; C07C233/31; C07C233/76; C07C235/46; C07C235/48; C07C235/50; C07C235/54; C07C237/32; C07C271/20; C07C275/24; C07C311/20; C07C311/29; C07D207/14; C07D211/56; C07D211/58; C07D213/40; C07D307/85; C07D309/14; C07D317/54; C07D317/58; C07D317/68; C07D317/72; C07D319/08; C07D319/18; C07D321/08; C07D335/02; C07D487/04; C07F9/36; C07K14/705; C07K14/72; C12P21/02; C12Q1/68

JP2001302606A
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Tetrahedron Letters 43(2002), p7495-7498

Patent Business Corporation Sender International Patent Office
Koji Hashimoto

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