IκB KINASE INHIBITOR

Japanese Patent JP2005298379

A

To provide an IκB kinase inhibitor inhibiting IκB kinase (a) causing NF-κB activation causing transcriptional enhancement of genes relating to immunity, inflammatory reaction, cell growth control and apoptosis, and (b) having inhibition of intracellular signaling of insulin and such properties as causing IRS-1 hypofunction (phosphorylation) causing inhibition of sugar intake into cells.

The IκB kinase inhibitor containing at least one selected from extracts, extracted from fruits or pericarps of a mangosteen (Garcinia mangostana L.), α-mangosteen and γ-mangosteen is provided, and a composition containing the inhibitor is provided.

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OIZUMI YASUSHI
YAMAGUNI TORU
ARAKAWA TSUTOMU
OSAWA KENJI
SHIMURA SUSUMU

JP2004114624A

October 27, 2005

April 08, 2004

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LOTTE CO LTD

C12N9/99; A23L29/00; A61K31/352; A61K36/00; A61K36/18; A61P1/04; A61P3/10; A61P5/14; A61P9/00; A61P9/10; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P19/06; A61P21/00; A61P21/04; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P31/12; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07D311/86; (IPC1-7): A61K31/352; A61K35/78; A61P1/04; A61P3/10; A61P5/14; A61P9/00; A61P9/10; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P19/06; A61P21/00; A61P21/04; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P31/12; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C12N9/99

JP2002047180A

2002-02-12

Haruo Hamada

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