KIR-BINDING AGENT AND METHOD OF USE THEREOF

Title:

KIR-BINDING AGENT AND METHOD OF USE THEREOF

Document Type and Number:

Japanese Patent JP2013100320

Kind Code:

A

Abstract:

To provide agents and methods that are capable of augmenting NK-mediated killing of target cells by reducing an inhibitory human Killer IgG-like Receptor (KIR) signalling.

The agent is selected from a monoclonal anti-KIR antibody or a cross-reactive KIR-binding agent, or fragments thereof for the preparation of a medicament for treatment of a cancer, an infectious disease, a viral infection, or immunodeficiency.

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Inventors:

PADKAER SOEREN BERG
WAGTMANN PETER ANDREAS NICOLAI REUMERT
SPEE PIETER
ZAHN STEFAN
KJAERGAARD KRISTIAN
SVENSSON ANDERS

Application Number:

JP2013003780A

Publication Date:

May 23, 2013

Filing Date:

January 11, 2013

Export Citation:

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Assignee:

NOVO NORDISK AS
INNATE PHARMA

International Classes:

A61K45/00; A61K39/395; A61P31/12; A61P31/14; A61P31/18; A61P35/00; A61P35/02; A61P43/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/08; C07K16/46

Other References:

JPN6011034401; Ｊ．　Ｅｘｐ．　Ｍｅｄ．，　（１９９０），　１７１，　［３］，　ｐ．６９５-７１４

Attorney, Agent or Firm:

Kurata Masatoshi
Yoshihiro Fukuhara
Makoto Nakamura
Nobuhisa Nogawa
Toshio Shirane
Takashi Mine

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