脂質粒子を含むキット、脂質粒子を利用した活性剤送達方法、および細胞の作製方法

Japanese Patent JP7209066

B2

The present embodiment provides a method for delivering activators to cells, wherein said activator containing lipid particles are brought into contact with the cells,where a compound represented by the formula (1):         Q-CHR₂     (1)whereinQ is represented by the following formula (1-Q):         R^Q1₂N-(CR^Q2₂)_q1-NR^Q1-(CR^Q2₂)_q2-*     (1-Q)whereineach R^Q1 is independently an alkyl,each R^Q2 is independently hydrogen or an alkyl,any two of R^Q1s and R^Q2s may link together to form a nitrogen-containing alicyclic ring,q1 is an integer of 1 to 4,q2 is an integer of 0 to 4, andthe mark * indicates the position bonding to -CHR₂; andeach R is independently an aliphatic group of C₁₂ to C_24;wherein said R is represented by the following formula (1-R):         -L^R1-C(=O)-O-L^R2     (1-R)whereL^R1 is alkylene andL^R2 is represented by the following formula (1-R2):         -CH₂-CH=CH-(CH₂)_r2-H     (1-R2)where r2 is an integer of 1 to 10.

Ishihara Mitsuko
Eiichi Akahoshi
Katsuyuki Naito
Emi Nozaki
Saeko Saruwatari

JP2021164955A

January 19, 2023

October 06, 2021

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Toshiba Corporation

A61K47/18; A61K9/127; A61K31/7088; A61K31/7105; A61K31/711; A61K31/713; A61K45/00; A61K47/22; A61K47/24; A61K47/28; A61K47/42; A61K48/00; A61P35/00; A61P43/00; C07C229/24; C07D233/02; C07D243/08; C07D251/04; C07D295/13; C07D295/15; C12N15/88

JP2015500835A
JP2017522376A

WO2019176079A1
WO2017111172A1

Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids,Journal of Controlled Release,2005年,107,276-287

Nakamura Yukitaka
Takeshi Sekine
Jun Suzuki
Maekawa Hideaki

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