Title:
クレブシエラ属の抗原
Document Type and Number:
Japanese Patent JP2010532657
Kind Code:
A
Abstract:
The present invention relates to isolated nucleic acid molecules which encode an antigen, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Klebsiella species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection and methods for the treatment or prevention of an infection. More specifically such antigens are produced by or associated with bacterial pathogens causing nosocomial infections or bacterial infections caused by Klebsiella pneumoniae.
Inventors:
Bakushi Shamira
Ships Thomas
Hanner Marx
Picaro jutta
Sakke Christina
Narge Esther
Randburg Urban
Tielel Dagmar
Maine Andreas
Noisis Birgit
Steyr Schneider Ulrike
Bon Gavine Alexander
Ships Thomas
Hanner Marx
Picaro jutta
Sakke Christina
Narge Esther
Randburg Urban
Tielel Dagmar
Maine Andreas
Noisis Birgit
Steyr Schneider Ulrike
Bon Gavine Alexander
Application Number:
JP2010504730A
Publication Date:
October 14, 2010
Filing Date:
April 29, 2008
Export Citation:
Assignee:
Intercell AG
International Classes:
C12N15/09; A61K35/74; A61K39/07; A61K39/39; A61K39/395; A61K48/00; A61P31/04; C07K14/26; C07K16/12; C07K16/18; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08; C12Q1/68; G01N33/53; G01N33/569; A61K39/00
Foreign References:
| US6610836B1 | 2003-08-26 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto