Title:
B型肝炎ウイルス及びEBウイルスの治療のためのL-ヌクレオシド
Document Type and Number:
Japanese Patent JP3899440
Kind Code:
B2
Abstract:
A method for the treatment of a host, and in particular, a human, infected with HBV or EBV is provided that includes administering an HBV- or EBV- treatment amount of an L-nucleoside of formula (I) wherein R is a purine or pyrimidine base. In one preferred embodiment, the active compound is 2'-fluoro-5-methyl- beta -L-arabinofuranosyluridine (also referred to as L-FMAU) This compound is a potent antiviral agent against HBV and EBV and exhibits low cytotoxicity. Other specific examples of active compounds include N1-(2'-deoxy-2'-fluoro- beta -L-arabinofuranosyl)-5-ethyluracil, N1-(2'-deoxy-2'-fluoro- beta -L-arabinofuranosyl)-5-iodocytosine), and N1-(2'-deoxy-2'-fluoro- beta -L-arabinofuranosyl)-5-iodouracil.
More Like This:
Inventors:
Chu, Chang, Kay
Chen, Yun Ji
Pie, Balakrishna, Es
Yao, Gyan Kin
Chen, Yun Ji
Pie, Balakrishna, Es
Yao, Gyan Kin
Application Number:
JP52024795A
Publication Date:
March 28, 2007
Filing Date:
January 30, 1995
Export Citation:
Assignee:
University, Of, Georgia, Research, Foundation, Incorporated
Yale, University
Yale, University
International Classes:
C07H19/09; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61P31/12; C07H19/00; C07H19/06; C07H19/16; C07H19/19; C07H19/20; C07H21/00
Domestic Patent References:
| JP60252418A | ||||
| JP6009403A | ||||
| JP2500524A |
Foreign References:
| US5246924 | ||||
| WO1992001704A1 |
Other References:
Antiviral Chemistry & Chemotherapy, 1991, Vol.2, No.2, pp.83-92
JOURNAL OF MEDICINAL CHEMISTRY, 1992, VOL.35, NO.22, pp.4214-4220
JOURNAL OF MEDICINAL CHEMISTRY, 1992, VOL.35, NO.22, pp.4214-4220
Attorney, Agent or Firm:
Akaoka Michio
Takumi Hayasaka
Takumi Hayasaka