標識したマレイミド化合物、それを調製する方法および高分子を標識するためのその使用 - COMPAGNIE GENERALE DES MATIERES NUCLEAIRES

Title:

標識したマレイミド化合物、それを調製する方法および高分子を標識するためのその使用

Document Type and Number:

Japanese Patent JP2006504640

Kind Code:

A

Abstract:

Fluorine-18-labelled maleimide compounds of general formula (I): in which: m represents an integer from 0 to 10; n represents an integer from 1 to 10; Y represents a group selected from optionally substituted monocyclic or bicyclic heterocyclic groups; X represents a radical of formula: (U)_a-((CR₁R₂)_b-(V)_c)_d-((CR₃R₄)_e-(W)_f)_g- in which: a, b, c, d, e, f and g represent each independently an integer from 0 to 10; U, V and W represent each independently -NR₁-, -O-, -S-, ethynyl, -CR₁-CR₂-, -(C-O)-, -(C-S)-, -C(-NR₁)-, -C(-O)O-, -(C-S)S-, -C(-NR₁)NR₂-, -CR₁R₂-, -CR₁OR₂- or -CR₁NR₂R₃-. Process for preparing these compounds; their use for labelling macromolecules, and complexes of these compounds with a macromolecule. Detection and analysis kit, or diagnosis kit, comprising the said complexes. Use of the complexes in a medical imaging process such as positron emission tomography (PET).

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Inventors:

Frederick Doll

Application Number:

JP2004516901A

Publication Date:

February 09, 2006

Filing Date:

June 30, 2003

Export Citation:

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Assignee:

COMPAGNIE GENERALE DES MATIERES NUCLEAIRES

International Classes:

C07D401/06; A61K51/00; A61K51/04; A61K51/08; C07D213/65; C07D213/74; C07D401/12; C07H21/02; C07H21/04; C07K1/13; C12N15/09

Domestic Patent References:

JPS62277331A	1987-12-02
JPH11243984A	1999-09-14
JPH09165377A	1997-06-24

Foreign References:

WO2001019799A2

2001-03-22

Attorney, Agent or Firm:

Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro

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