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Title:
LABELING REAGENT, METHOD FOR SYNTHESIZING SUCH REAGENT AND METHOD FOR DETECTING BIOLOGICAL MOLECULE
Document Type and Number:
Japanese Patent JP2009137954
Kind Code:
A
Abstract:

To provide a temperature-stable labeling reagent.

A temperature-stable labeling reagent of the formula is provided, wherein R1 represents H or an alkyl, aryl or substituted aryl group; R2 represents a detectable marker or at least two detectable markers linked together by at least one multimeric structure; L is a linking arm containing a linear succession of at least two covalent bonds; n is an integer equal to 0 or 1; R3 and R4 represent independently of each other: H, NO2, Cl, Br, F, I, R2-(L)n-Y-X-, OR, SR, NR2, R, NHCOR, CONHR, COOR with R=alkyl or aryl; A is a linking arm containing at least one covalent double bond allowing conjugation of the diazo functional group with the aromatic ring; and u is an integer of 0 to 2, preferably equal to 0 or 1.


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Inventors:
BOURGET CECILE
LHOMME JEAN
LAAYOUN ALI
KOTERA MITSUHARU
TREVISIOL EMMANUELLE
MENOU LIONEL
BERNAL MENDEZ ELOY
Application Number:
JP2008301646A
Publication Date:
June 25, 2009
Filing Date:
November 26, 2008
Export Citation:
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Assignee:
BIO MERIEUX
UNIV GRENOBLE 1
CT NATL DE LA RECH SCIENT
International Classes:
C07C245/14; G01N33/58; C07C245/18; C07D209/08; C07D209/14; C07D311/90; C07D495/04; C07H21/04; C09B23/00; C09B69/00; C12N15/09; C12Q1/68; G01N33/50; G01N33/533
Domestic Patent References:
JP4494717B22010-06-30
Other References:
JPN5003017764; MASANOBU SHIGA: ANALYTICAL SCIENCES V9N4, 1993, P553-556
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro