Title:
LACTAM-FREE AMINO ACID
Document Type and Number:
Japanese Patent JP3261123
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject stable and high-purity compound by hydrolyzing an amino acid containing a lactam or a lactam with a mixture of concentrated sulfuric acid and water and then conducting ion exchange of the reaction product.
SOLUTION: (i) A compound of formula II containing a compound of formula I (n is 5) or a compound of formula I alone is hydrolyzed with an isovolume mixture of concentrated mineral acid (hydrochloric acid) and water to form an acid-addition salt and (ii) the acid-addition salt is subjected to ion exchange to decrease amounts of the compound of formula I and mineral acid anions each contained in the compound of formula II down to <0.5 wt.% and <20 ppm, respectively. A pharmacological composition is preferably formed by being mixed with a pharmaceutically permissible adjuvant (e.g. hydroxypropyl methyl cellulose) which does not promote the formation of the compound of formula I.
Inventors:
AUGART HELMUT
GEBHARDT UWE
HERRMANN WOLFGANG
GEBHARDT UWE
HERRMANN WOLFGANG
Application Number:
JP2000270023A
Publication Date:
February 25, 2002
Filing Date:
August 24, 1990
Export Citation:
Assignee:
GOEDECKE AG
International Classes:
A61K9/20; A61K9/48; A61K31/195; A61K31/197; A61K31/40; A61K31/4015; A61K31/403; A61K47/02; A61K47/04; A61K47/26; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/40; A61P25/00; A61P25/08; A61P25/28; C07C227/22; C07C229/28; C07D207/263; C07D209/54; (IPC1-7): C07C227/22; A61K9/20; A61K9/48; A61K31/197; A61K47/04; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/40; A61P25/00; A61P25/08; A61P25/28; C07C229/28
Domestic Patent References:
| JP52113977A | ||||
| JP5287142A |
Attorney, Agent or Firm:
Takehiko Suzue (2 outside)