Title:
鏡像異性体純度が高いラクタム置換プロパン酸誘導体並びにそれらの製造方法及び使用方法
Document Type and Number:
Japanese Patent JP2004509947
Kind Code:
A
Abstract:
The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one step of the reaction sequence, asymmetric hydrogenation of a lactam-enamide was performed to produce an intermediate that can ultimately be converted to a series of pharmaceutical compounds. The invention also contemplates the in situ synthesis of an intermediate of the multi-step synthesis, which provides economic advantages to the overall synthesis of the lactam compounds.
Inventors:
Neil Warren, Boaz
Divenham, Sheryl Davis
Divenham, Sheryl Davis
Application Number:
JP2002531091A
Publication Date:
April 02, 2004
Filing Date:
September 28, 2001
Export Citation:
Assignee:
EASTMAN CHEMICAL COMPANY
International Classes:
B01J31/24; C07B61/00; C07C231/18; C07C253/30; C07C269/06; C07D203/04; C07D205/08; C07D207/27; C07D211/76; C07D223/10; C07D225/02; C07F9/553; C07F9/564; C07F9/568; C07F9/572; C07F9/576; C07F9/59; C07C233/47; C07C233/83; C07C233/84; C07C255/60; C07C271/22; C07D207/26; (IPC1-7): C07D207/27; B01J31/24; C07F9/553; C07F9/564; C07F9/568; C07F9/572; C07F9/576
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Koji Takeuchi
Masaya Nishiyama
Higuchi Souji
Jun Tsuruta
Koji Takeuchi
Masaya Nishiyama
Higuchi Souji