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Patent Searching and Data


Title:
LACTONE COMPOUND AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JPH06329696
Kind Code:
A
Abstract:

PURPOSE: To provide a new latctone compound composed of a 1α, 25- dihydroxyvitamin D3-based lactone compound, having a calcium concentration reduction effect, a tumor cell growth inhibitory effect and an osteogenesis promotion effect and useful, e.g. as a medicine such as an osteogensis promoting medicine.

CONSTITUTION: The new lactone compound composed of a compound represented by formula III, its 23 position and/or 25 position stereoisomer or their mixture is produced by halogenating a lactone compound represented by formula I [R1 to R3 are each H, a tri(1 to 7C hydrocarbon)silyl, a 2 to 8C acyl or a group capable of forming an acetal bond together with O of OH; (m) and (n) are each 0 or 1 provided that both (m) and (n) are not 0], its 23 position and/or 25 position stereoisomer or their mixture, then treating the resultant reaction product with a basic compound, applying a deprotection treatment thereto to obtain a lactone compound of formula II in case a hydroxyl-protection group is contained and subsequently carrying out a photoreaction-isomerization reaction.


Inventors:
Tanabe, Masayasu
Manabe, Kenji
Tomimori, Koji
Hasato, Atsuo
Takenouchi, Osami
Azuma, Yoshiaki
Application Number:
JP1994000012542
Publication Date:
November 29, 1994
Filing Date:
February 04, 1994
Export Citation:
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Assignee:
TEIJIN LTD
International Classes:
A61K31/585; A61K31/59; A61P3/02; A61P3/06; A61P3/14; A61P43/00; C07C401/00; C07D307/32; C07D307/33; C07D309/30; C07J17/00; C07J19/00; (IPC1-7): C07J19/00; A61K31/585; A61K31/59; C07D307/33; C07D309/30
Attorney, Agent or Firm:
前田 純博