10-ヒドロキシ-7-エチルカンプトテシンのラクトン安定処方物

Japanese Patent JP4177890

B2

10-hydroxy 7-ethyl camptothecin (HECPT), an active metabolite of the camptothecin analog CPT-11, is poorly soluble in water. Because of its poor water solubility, HECPT has not been directly administered by parenteral or oral routes in human patients for the purpose of inhibiting the growth of cancer cells. There is also unpredictable interpatient variability in the metabolic production of HECPT from CPT-11 which limits the utility of CPT-11. This invention overcomes these limitations by teaching novel pharmaceutically acceptable lactone stable HECPT formulations for the direct administration of HECPT. The claimed invention also describes novel dosages, schedules, and routes of administration of the lactone stable HECPT formulations to patients with various forms of cancer.

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Haridas, Cochat
Frederick Harman

JP51717195A

November 05, 2008

December 19, 1994

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Bio Numeric Pharmaceuticals, Inc.

A61K31/4745; C07D491/22; A61K9/00; A61K9/08; A61K9/107; A61K9/48; A61K31/47; A61K47/12; A61K47/16; A61K47/18; A61K47/26; A61K47/28; A61P35/00

JP63238098A
JP2115126A
JP62048629A

E.Rubin et al., Proceedings of the American Association for Cancer Research, 米国, 1994年 3月, Vol.35, p.245
J.H.Beijnen et al., Journal of Chromatography, Biomedical Applications, Elsevier Science Publishers B.V., 1993年 7月23日, Vol.617/No.1, p.111-117

Mitsuo Kata
Yoshiyuki Osuga

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