Title:
ラメラリン-クラスアルカロイドの治療方法への使用
Document Type and Number:
Japanese Patent JP4153992
Kind Code:
B2
Abstract:
The lamellarin compounds disclosed herein have been found to be inhibitors of MDR, i.e., acquired multidrug resistance, which has become a major problem in the treatment of various cancers. The lamellarin compounds disclosed herein have also been found to be cytotoxic to MDR cells. MDR is believed to be associated with certain alterations in tumor cells, including an over-expression of a certain high molecular weight membrane glycoprotein and a decrease in the ability of the tumor cell to accumulate and retain chemotherapeutic agents. The present invention is thus directed to methods of treating MDR-type tumors with an effective anti-MDR amount (either inhibitory or cytotoxic) of one or more lamellarin compounds, which compounds have been found to be effective antitumoral agents against MDR cells.
Inventors:
Jose Luis Fernandez, Puentes
Garcia Gravaros, Delores
Rodriguez Quesada, Anna
Garcia Gravaros, Delores
Rodriguez Quesada, Anna
Application Number:
JP50428597A
Publication Date:
September 24, 2008
Filing Date:
June 26, 1996
Export Citation:
Assignee:
Pharma, Sociedad Anonima
International Classes:
A61K31/435; A61K31/437; C07D491/147; A61K31/4433; A61K31/4745; A61K31/475; A61K31/65; A61K31/70; A61K31/704; A61K35/56; A61K38/08; A61P35/00; A61P43/00
Other References:
Anthony R. Carroll et al., Australian Journal of Chemistry, 1993年, Vol.46, No.4, p.489-501
Sylvia Urban et al., Australian Journal of Chemistry, 1994年, Vol.47, No.10, p.1919-1924
Sylvia Urban et al., Australian Journal of Chemistry, 1994年, Vol.47, No.10, p.1919-1924
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Akiko Yamaguchi
Hajime Asamura
Yukihiro Ikeda
Akiko Yamaguchi