アルツハイマー病の治療のための大環状第三アミンβ-セクレターゼ阻害剤

Title:

アルツハイマー病の治療のための大環状第三アミンβ-セクレターゼ阻害剤

Document Type and Number:

Japanese Patent JP2008520670

Kind Code:

A

Abstract:

The present invention is directed to macrocyclic tertiary amine compounds represented by general formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

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Inventors:

Nan Therme, Filip Gee
Radija Pakshi, Hemaka A
Sernitsk, Harold Gee
Linsley, Stacy
Moore, Keith Pee
Stachel, Xieong Jei

Application Number:

JP2007543137A

Publication Date:

June 19, 2008

Filing Date:

November 14, 2005

Export Citation:

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Assignee:

MERCK & COMPANY INCOPORATED

International Classes:

C07D273/01; A61K31/335; A61K31/395; A61K31/422; A61P25/28; A61P43/00; C07D313/00; C07D321/00; C07D323/00; C07D498/08

Foreign References:

WO2002100399A1	2002-12-19
WO2004062625A2	2004-07-29

Attorney, Agent or Firm:

Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura

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