Title:
ラタノプロストの合成方法及び中間体
Document Type and Number:
Japanese Patent JP2004535465
Kind Code:
A
Abstract:
The present invention is a novel intermediate, compound of the formula (VI)and salts thereof. In addition, the invention includes a process for the preparation of a 15(S)-prostaglandin intermediates compounds (IV) and (XVIII) which comprises (1) contacting a the corresponding enone with (-)-chlorodiisopinocampheylborane while maintaining the reaction mixture temperature in the range of from about -50° to about 0° and (2) contacting the reaction mixture of step (1) with a boron complexing agent.
Inventors:
Henneger, Kevin Edward
Application Number:
JP2003513929A
Publication Date:
November 25, 2004
Filing Date:
June 24, 2002
Export Citation:
Assignee:
PHARMACIA&UPJOHN COMPANY
International Classes:
A61K31/5575; A61P27/02; C07C59/11; C07C59/54; C07C59/72; C07D307/83; C07C405/00; C07D307/935; (IPC1-7): C07C59/11; A61P27/02; C07C59/54; C07D307/83
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama
Takashi Ishida
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama