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Title:
LEPTOCILLIN BASED COMPOUND AND PRODUCTION THEREOF
Document Type and Number:
Japanese Patent JP01110658
Kind Code:
A
Abstract:

NEW MATERIAL:A compound expressed by formula I or formula II (R is alkoxy).

USE: An antibiotic. Useful as an antigermicide because of having antigerm activity.

PREPARATION: L-179 Strain (FERM P-9661) belonging to the genus Leptosphaeri is cultivated in a culture medium containing normal nutritive under aerobic conditions at 10W30°C for 3W10 day and extracted with acetone-ethyl acetate, etc., to afford the compound expressed by formula I. The compound expressed by formula I is then subjected to alkali treatment to provide the compound expressed by formula II. Properties of the compound expressed by formula I: Appearance, colorless needle crystal; elemental analysis, C 71.00%, H 4.99%, N 8.67%; mol.wt., 320; molecular formura C19H16N2O3; specific rotation, [α]D22=+34.7°; solubility, soluble in methanol, ethanol, ethyl acetate and chloro form and insoluble in water, etc. Properties of the compound expressed by formula II: appearance, colorless needle crystal; elemental analysis, C 74.18%, H 4.64%, N 13.35%; mol.wt., 210; molecular formula, C13H10N2O, etc.


Inventors:
Ito, Jiro
Gomi, Shuichi
Shomura, Takashi
Mikawa, Takashi
Takahashi, Noriko
Ogishi, Haruyuki
Application Number:
JP1987000266002
Publication Date:
April 27, 1989
Filing Date:
October 21, 1987
Export Citation:
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Assignee:
MEIJI SEIKA KAISHA LTD
MITSUBISHI KASEI CORP
International Classes:
C12P13/00; A61K31/275; A61P31/04; C07C67/00; C07C241/00; C07C291/10; C12R1/645; C12P13/00; A61K31/275; A61P31/00; C07C67/00; C07C241/00; C07C291/00; (IPC1-7): A61K31/275; C07C119/02; C12P13/00



 
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