Title:
LEUKEMIA STEM CELL MARKER
Document Type and Number:
Japanese Patent JP2015231375
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To find a molecular target specific to a human leukemia stem cell (LSC), and provide treatment means or the like leading to complete cure of acute myeloid leukemia (AML).SOLUTION: There are provided: a testing method of predicting first occurrence or recurrence of AML includes (1) a process of measuring an expression level of an LSC marker gene in a biological sample collected from a subject regarding a transcription product or a translation product of the gene, and (2) a process of comparing an expression level obtained from the measurement process with a reference value, in which the LSC marker gene is composed of 2 to 218 genes; a therapeutic agent of AML targeting an LSC containing a substance which can suppress expression of a gene selected from the LSC marker gene or activity of a translation product of the gene, as an active ingredient; and a manufacturing method of a sample containing hematopoietic cells for autologous or allograft transplant to an AML patient in which the method includes a process of obtaining a sample from which the LSC was purged by using at least one kind of LSC marker as an indicator.
Inventors:
ISHIKAWA FUMIHIKO
OBARA OSAMU
SAITO YORIKO
KITAMURA HIROSHI
HIJIKATA ATSUSHI
OZAWA HIDETOSHI
LEONARD D SHULTZ
OBARA OSAMU
SAITO YORIKO
KITAMURA HIROSHI
HIJIKATA ATSUSHI
OZAWA HIDETOSHI
LEONARD D SHULTZ
Application Number:
JP2015135949A
Publication Date:
December 24, 2015
Filing Date:
July 07, 2015
Export Citation:
Assignee:
RIKAGAKU KENKYUSHO
International Classes:
C12Q1/68; A61K31/7088; A61K31/713; A61K35/28; A61K39/395; A61K45/00; A61K47/48; A61K48/00; A61P35/02; A61P43/00; C12N5/078; C12N5/0797; C12N5/095; C12Q1/04; G01N33/48; G01N33/50; G01N33/68
Domestic Patent References:
| JP2002530293A | 2002-09-17 | |||
| JP2005501516A | 2005-01-20 |
Other References:
日本臨床免疫学会会誌, vol. 第30巻、第4号, JPN6010021850, 2007, pages 3 - 9
第66回 日本癌学会学術総会記事, JPN6010021852, 2007, pages 76 - 77
PROC. NATL. ACAD. SCI. U.S.A., vol. Vol. 104, No. 26, JPN6010021854, 2007, pages 11008 - 11013
GENES, CHROMOSOMES AND CANCER, vol. Vol. 47, JPN6010021856, 2008, pages 8 - 20
"Ｍｉｘｅｄ Ｌｅｕｋｅｍｉａをめぐる諸問題", 医学のあゆみ, vol. 第190巻, JPN6017012068, 1999, pages 第406-410頁
CANCER RESEARCH, vol. Vol. 53, JPN6017012067, 1993, pages 675 - 680
第66回 日本癌学会学術総会記事, JPN6010021852, 2007, pages 76 - 77
PROC. NATL. ACAD. SCI. U.S.A., vol. Vol. 104, No. 26, JPN6010021854, 2007, pages 11008 - 11013
GENES, CHROMOSOMES AND CANCER, vol. Vol. 47, JPN6010021856, 2008, pages 8 - 20
"Ｍｉｘｅｄ Ｌｅｕｋｅｍｉａをめぐる諸問題", 医学のあゆみ, vol. 第190巻, JPN6017012068, 1999, pages 第406-410頁
CANCER RESEARCH, vol. Vol. 53, JPN6017012067, 1993, pages 675 - 680
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma