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Patent Searching and Data


Title:
LEUKOTRIENE ANTAGONIST
Document Type and Number:
Japanese Patent JPH0952899
Kind Code:
A
Abstract:

PURPOSE: To obtain the subject antagonist useful for the therapy, prophylaxis, etc., of allergosis, inflammatory affection, cardiovascular diseases, etc., by compounding a terpene derivative including new compounds isolated from an extract of a plant belonging to the family Celastraceae as an active ingredient.

CONSTITUTION: This leukotriene antagonist useful for the thereby, prophylaxis, etc., of allergosis, inflammatory affection, cardiovascular diseases, etc., contains as an active ingredient a diterpene derivative, a triterpene derivative, etc., of formula I (R1 is a lower alkyl, H or carbonyl; R2 and R3 are each a lower alkyl, H or CH2OH; R4 is OH, H or =O; R5 and R6 are each a lower alkyl, H or carbonyl; R7 is a lower alkyl; A is a group of formula II or formula III, etc.) isolated from an extract of Tripterygium wilfordii, a plant belonging to the family Celastraceae, Tripterygium regelii in the genus Tripterygium, Celastrus orbiculatus in the genus Celastrus, Euonymus alatus, Euonymus sieboldianus, etc., in the genus Euonymus, Microtropis japonica in the genus Microtropis, etc. The compounds of formulas III and IV are new compounds, respectively, among these compounds.


Inventors:
Morota, Takashi
Saito, Kazuko
Komatsu, Yasuhiro
YO, Joki
Shin, Mansho
JO, Ryokuko
Application Number:
JP1994000261651
Publication Date:
February 25, 1997
Filing Date:
September 30, 1994
Export Citation:
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Assignee:
TSUMURA & CO
SHANGHAI MEDICAL UNIV ZHONGSHAN
International Classes:
A61K31/56; A61K31/12; A61K31/58; A61K36/18; A61P9/00; A61P29/00; A61P37/08; A61P43/00; C07C49/753; C07C50/38; C07J63/00; (IPC1-7): C07J63/00; A61K31/12; A61K31/56; A61K31/58; A61K35/78; C07C49/753; C07C50/38