PURPOSE: To obtain the subject antagonist useful for the therapy, prophylaxis, etc., of allergosis, inflammatory affection, cardiovascular diseases, etc., by compounding a terpene derivative including new compounds isolated from an extract of a plant belonging to the family Celastraceae as an active ingredient.
CONSTITUTION: This leukotriene antagonist useful for the thereby, prophylaxis, etc., of allergosis, inflammatory affection, cardiovascular diseases, etc., contains as an active ingredient a diterpene derivative, a triterpene derivative, etc., of formula I (R1 is a lower alkyl, H or carbonyl; R2 and R3 are each a lower alkyl, H or CH2OH; R4 is OH, H or =O; R5 and R6 are each a lower alkyl, H or carbonyl; R7 is a lower alkyl; A is a group of formula II or formula III, etc.) isolated from an extract of Tripterygium wilfordii, a plant belonging to the family Celastraceae, Tripterygium regelii in the genus Tripterygium, Celastrus orbiculatus in the genus Celastrus, Euonymus alatus, Euonymus sieboldianus, etc., in the genus Euonymus, Microtropis japonica in the genus Microtropis, etc. The compounds of formulas III and IV are new compounds, respectively, among these compounds.
SHANGHAI MEDICAL UNIV ZHONGSHAN