NEW MATERIAL: Compounds of the formula I, in which (q) represents 0-2, R1 represents a group of the formula II (each of (a) and (c) denotes O or 1, (b) denotes 3-4, each of L and T denotes O, S, CH2 with the proviso that it does not denote S if (q) is 1 or 2, B denotes alkyl, ethynyl, CF3, furanyl or phenyl etc.), each of R2 and A represents H, CF3, alkyl, halogen or OH etc., Y represents COR3 or a group of the formula III (R3 denotes OH, NH2 or alkoxy etc., (n) denotes 0 or 1, and (p) denotes 0-2), X represents H, OH or alkyl etc., Z represents COR3 or tetrazolyl, R represents a group of the formula IV ((m) denotes 0-6, each of R4 and R5 denotes H or alkyl and W represents tetrazole or thiazole etc.), or their salts.
EXAMPLE: 2-(2-Dodecylphenyl)-2-[(1-methyl-5-tetrazolyl)thiol] acetic acid.
USE: Leukotriene antagonists useful for depression of antigen-derived respiratory anaphylaxis.
PREPARATION: A substd. thiol such as the formula RSH is allowed to react with a compd. of the formula V to obtain a compd. of the formula I.
RARUFU FUROIDO HOORU
AIRIIN NIJIYOORE YUUJINSUKASU
