Title:
LEUKOTRIENE-ANTAGONIZING BENZOIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JPH09169712
Kind Code:
A
Abstract:
To obtain the subject new compound useful for preventing and treating a respiratory disease, especially in acute and chronic inflammatory stage of respiratory tract.
This benzoic acid derivative is represented by formula I [R' is H or a ≤6C alkyl; P and Q are each O, S, etc.; X is O, S or CONH; T is ethylene; O, etc.; Y is COOH, etc.; (m) is an integer of 0-6; (n) is an integer of 0-4] and its salt, e.g. 3-aza-4-{5-carboxy-2-[3-(4-phenoxybutoxy) phenylpropoxy]-4-oxobutanoic acid. The compound of formula I is obtained by reacting a compound of formula II (Hal is Cl, Br, etc.) with a compound of formula III, e.g. in an inert solvent such as ethers, e.g. in the presence of an alkali metal alcoholate at -80 to +70°C.
Inventors:
TOREBAA SUMISU ABURAMU
NAIJIERU JIEIMUZU KASUBAATO
HIRARII PATORISHIA FURANSHISU
FUIRITSUPU JIYON GAADEINAA
PIITAA NOOMAN
SUCHIIBUN RICHIYAADO TADOHOOPU
NAIJIERU JIEIMUZU KASUBAATO
HIRARII PATORISHIA FURANSHISU
FUIRITSUPU JIYON GAADEINAA
PIITAA NOOMAN
SUCHIIBUN RICHIYAADO TADOHOOPU
Application Number:
JP32584196A
Publication Date:
June 30, 1997
Filing Date:
November 22, 1996
Export Citation:
Assignee:
BAYER AG
International Classes:
A61K31/085; A61K31/155; A61K31/165; A61K31/195; A61K31/245; A61P9/00; A61P11/00; A61P29/00; A61P43/00; C07C231/02; C07C231/12; C07C233/54; C07C235/24; C07C235/38; C07C235/58; C07C235/60; C07C235/64; C07C303/38; C07C303/40; C07C309/65; C07C311/08; C07C311/21; A61K31/60; C07C319/20; C07C323/62; C07C323/63; (IPC1-7): C07C233/54; A61K31/085; A61K31/155; A61K31/165; A61K31/195; A61K31/245; A61K31/60; C07C231/02; C07C231/12; C07C235/38; C07C235/58; C07C235/60; C07C235/64; C07C303/38; C07C303/40; C07C309/65; C07C311/08; C07C311/21; C07C319/20; C07C323/62; C07C323/63
Attorney, Agent or Firm:
Heiyoshi Odashima