Title:
代謝調節型グルタミン酸受容体のリガンド、及び、NAALADaseの阻害剤
Document Type and Number:
Japanese Patent JP5095050
Kind Code:
B2
Abstract:
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.
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Inventors:
Kozykowski Alan Pee
Robleski Jardy
Nan Fergin
Robleski Jardy
Nan Fergin
Application Number:
JP2000614262A
Publication Date:
December 12, 2012
Filing Date:
April 27, 2000
Export Citation:
Assignee:
GEORGETOWN UNIVERSITY
International Classes:
A61K31/662; A61K31/194; C07C59/347; A61K31/197; A61K31/198; A61K31/22; A61K31/225; A61P3/00; A61P9/00; A61P9/10; A61P25/00; A61P25/02; A61P25/08; A61P25/16; A61P25/28; A61P31/04; A61P39/00; A61P41/00; A61P43/00; C07C69/716; C07C275/16; C07C335/08; C07F9/30; C07F9/32
Foreign References:
| WO1998045256A1 | ||||
| WO1998045257A1 |
Other References:
Journal of Medicinal Chemistry,1996年,Vol.39, No. 2,619-622
Attorney, Agent or Firm:
Tsutomu Kanakubo