PURPOSE: To obtain a bacterium preparation capable of being administered orally, having excellent acid resistance by sticking lipid powder to the whole circumferential surface of bacterium powder pulverized by lyophilization.

CONSTITUTION: Lipid powder having ≥40°C melting point is brought into contact with or collided against bacterium powder (preferably one having 0.5.μm-1mm particle diameter) itself or pulverized by lyophilization or mixed bacterium powder containing edible powder (e.g. lactic acid, milk powder or starch) and the lipid powder is stuck to the whole circumferential surface of the bacterium preparation. Bacteria in the intestine such as Lactobacillus bifidus, lactic acid bacillus, yeast fungus, bacteria belonging to the genus Streptococcus are used as the bacterium powder. Natural fats and oils, wax, fatty acid, etc., are used as the lipid powder, the ratio of particle diameter of the bacterium powder and the lipid powder is (1:1)-(1:0.0001) and the blending ratio is 0.5-50 (adjusted in relation to the ratio of particle diameter).