Title:
脂質組成物及びその使用
Document Type and Number:
Japanese Patent JP2007524667
Kind Code:
A
Abstract:
The invention provides a composition suitable for use as a transfection agent, comprising a cationic cardiolipin analogue and, another lipid species. The composition of the present invention can facilitate transfection of a wide variety of polynucleotide species (e.g., oligodeoxyribonucleotides, plasmids, RNAi species, etc.). Moreover, the transfection agent of the present invention is effective in promoting transfection of primary cell cultures as well as transformed cells. Also, the inventive transfection agent is suitable for use both in vitro and in vivo. The inventive composition has additional uses as well, such as delivery of a variety of active agents, dermatological and cosmetic uses, and uses in agriculture. The invention further provides a method of introducing an active agent into a cell by contacting the cell with the inventive composition. The invention further provides a method of inhibiting the growth of neoplastic cells and a method of treating a patient suffering from a neoplastic disease by employing the inventive composition, wherein an active agent is an antineoplastic agent. The invention further provides a method for validating a genetic target, comprising (a) administering to a cell a composition comprising a cationic liposome and a siRNA, whereby the siRNA enters the cell inhibits the expression of a gene within the cell and (b) assaying for the inhibition of the gene. The method also provides a fluorescent/ luminescent cationic cardiolipin analogue and compositions including such analogues. Using a cationic cardiolipin analogue, the invention provides a method of tracking the migration of a lipid substance within an animal.
Inventors:
Ahmad, Mogisu You.
Shake, Saifudin
Ant, showcas
Chien, pay-you
Jamil, harris
Chang, Zia-i
Ugu, Sydney
Chan, Qi-i
One, Zinkan
Bamidy Patty, Chasteli
Ahmad, The Feel
Ahmad, Imran
Shake, Saifudin
Ant, showcas
Chien, pay-you
Jamil, harris
Chang, Zia-i
Ugu, Sydney
Chan, Qi-i
One, Zinkan
Bamidy Patty, Chasteli
Ahmad, The Feel
Ahmad, Imran
Application Number:
JP2006549412A
Publication Date:
August 30, 2007
Filing Date:
January 07, 2005
Export Citation:
Assignee:
Neo Farm, Incorporated
International Classes:
A61K47/18; A61K9/127; A61K31/14; A61K31/355; A61K31/575; A61K31/685; A61K31/7088; A61K31/7105; A61K31/711; A61K45/06; A61K47/24; A61K47/26; A61K47/28; A61K47/44; A61K48/00; A61P35/00; C12N15/09; C12N15/11; C12N15/113; C12Q1/02; C12Q1/68
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura