ｓｉＲＮＡ細胞内送達のための脂質膜構造体 - National University Corporation Hokkaido University

Title:

ｓｉＲＮＡ細胞内送達のための脂質膜構造体

Document Type and Number:

Japanese Patent JP7202009

Kind Code:

B2

Abstract:

A lipid membrane structure includes, as lipid components, a lipid compound represented by Formula (I): (R¹)(R²)C(OH)-(CH₂)_a-(O-CO)_b-X ... (I)[in the formula, a represents an integer of 3 to 5; b represents an integer of 0 or 1; R¹and R²each independently represents a linear hydrocarbon group that may have -CO-O-; and X represents a 5- to 7-membered non-aromatic heterocyclic group or a group represented by Formula (B) (in the formula, d represents an integer of 0 to 3, and R³and R⁴each independently represents a C_1-4alkyl group or a C_2-4alkenyl group, where, R³and R⁴may be bonded to each other to form a 5- to 7-membered non-aromatic heterocycle (where, one or two C_1-4alkyl groups or C_2-4alkenyl groups may be substituted on the ring)].

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Inventors:

Hideyoshi Harashima
Yusuke Sato

Application Number:

JP2019525575A

Publication Date:

January 11, 2023

Filing Date:

June 15, 2018

Export Citation:

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Assignee:

National University Corporation Hokkaido University

International Classes:

C07C215/08; A61K9/127; A61K31/713; A61K47/18; A61P35/00; A61P37/02; C07C219/06; C07C219/08; C07C229/12; C07D211/62; C07D295/088; C07D295/15

Domestic Patent References:

JP2016084297A
JP2014500233A

Foreign References:

US20120172411
WO2015178343A1
WO2016153012A1

Other References:

中村孝司、他,化学工業,化学工業社,2016年,7月号,第477~482頁
SATO, Y. et al.,Molecular Therapy,2016年,Vol. 24, No. 4,pp. 788-795

Attorney, Agent or Firm:

Kazuzumi Nishizawa
Eisuke Ito
Hirotaka Haruta

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