Title:
LIPID NANOPARTICLE
Document Type and Number:
Japanese Patent JP2019151589
Kind Code:
A
Abstract:
To provide lipid nanoparticles useful as a carrier for drug active ingredients such as siRNA and having excellent delivery efficiency even if the particle diameter has become small.SOLUTION: Provided is a lipid nanoparticle containing a cationic lipid represented by the following general formula (I) [a is an integer from 3 to 5; b is 0 or 1; Rand Rare each independently a group having 20 or more carbon atoms represented by the following general formula (A) (q represents an integer from 1 to 9, r represents 0 or 1, s represents an integer from 1 to 3, t represents 0 or 1, u represents an integer from 1 to 8, c represents 0 or 1, v represents an integer from 4 to 12); X represents a group represented by the following general formula (B) (d is an integer of 0 to 3, Rand Rare each independently a Calkyl group or a Calkenyl group) or a 5- to 7-membered non-aromatic heterocyclic group]; and a neutral lipid with a hydrophilic group having 2 or more carbon atoms and a linear hydrophobic group.SELECTED DRAWING: None
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Inventors:
SATO YUSUKE
HARASHIMA HIDEYOSHI
OKABE NANA
HARASHIMA HIDEYOSHI
OKABE NANA
Application Number:
JP2018038082A
Publication Date:
September 12, 2019
Filing Date:
March 02, 2018
Export Citation:
Assignee:
UNIV HOKKAIDO
International Classes:
A61K47/18; A61K9/127; A61K9/14; A61K31/7105; A61K31/713; A61K38/02; A61K47/22; A61K47/24
Attorney, Agent or Firm:
Nishizawa Kazumi
Eisuke Ito
Taichi Hasegawa
Hirotaka Haruta
Eisuke Ito
Taichi Hasegawa
Hirotaka Haruta