Title:
ｂｃｌ−２を抑制するアンチセンスオリゴヌクレオチドの脂質ナノ粒子及びその調製方法
Document Type and Number:
Japanese Patent JP6986563
Kind Code:
B2
Abstract:
The invention discloses a lipid nanoparticle for antisense oligonucleotides inhibiting bcl-2 and belongs to the technical field of biology. The lipid nanoparticle for antisense oligonucleotides inhibiting bcl-2 is prepared by coating an antisense oligonucleotide with a membrane material, and the nucleic acid sequence is 5'-TCT CCC AGC GTG CGC CAT-3', or 5' UCU CCC AGC GTG CGC CAU 3'. And a method for preparing the same is disclosed. The nanoparticles of the present invention have a fairly good inhibitory effect on the growth of tumor cells and specific target genes, and particularly have a fairly good inhibitory effect on KB cervical cancer cells.
Inventors:
Light
Chen Bunchu
Hatari
Chen Bunchu
Hatari
Application Number:
JP2019541841A
Publication Date:
December 22, 2021
Filing Date:
October 13, 2017
Export Citation:
Assignee:
Nanjing green leaf system drug Co.
Nanjing Love Sai Katsu Delivery American biomedical Drug Co., Ltd.
Nanjing Love Sai Katsu Delivery American biomedical Drug Co., Ltd.
International Classes:
A61K31/7105; A61K9/51; A61K31/711; A61K47/02; A61K47/24; A61K47/26; A61K47/28; A61P35/00; C12N15/113
Domestic Patent References:
| JP2011529912A | ||||
| JP2012509273A | ||||
| JP2012509258A | ||||
| JP2015525209A | ||||
| JP2011121974A |
Other References:
Journal of Biological Chemistry,1998年,Vol.273, No.25,p.15621-15627
Advanced Drug Delivery Reviews,2016年02月18日,Vol.99,p.129-137
Advanced Drug Delivery Reviews,2016年02月18日,Vol.99,p.129-137
Attorney, Agent or Firm:
Hiroe Associates Patent Office