Title:
LIPOIC ACID DERIVATIVES
Document Type and Number:
Japanese Patent JP2014159398
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide lipoic acid derivatives or salts thereof which selectively kill tumor cells by altering cancer cell metabolism and signal transduction pathways linked to the Warburg Effect.SOLUTION: This invention provides lipoic acid derivatives having formula (I) or salts thereof, where Rand Rare independently selected from the group consisting of acyl, heteroaryl, imidoyl, organometallic aryl, and alkyl-organometallic aryl and can be unsubstituted or substituted; and x is 0-16.
Inventors:
PAUL BINGHAM
TOM KWOK
ZACHAR ZUZANA
TOM KWOK
ZACHAR ZUZANA
Application Number:
JP2013232829A
Publication Date:
September 04, 2014
Filing Date:
November 11, 2013
Export Citation:
Assignee:
CORNERSTONE PHARMACEUTICALS INC
International Classes:
C07C323/52; A61K31/20; A61K31/295; A61K31/385; A61K31/4025; A61K31/4188; A61K31/428; A61K31/44; A61K31/4436; A61K31/444; A61K31/4709; A61P35/00; A61P43/00; C07C323/56; C07C327/32; C07D207/34; C07D213/64; C07D213/71; C07D213/81; C07D215/36; C07D339/08; C07D409/04; C07D519/00; C07F17/02
Domestic Patent References:
| JPS4028347B1 | ||||
| JP2002528446A | 2002-09-03 |
Foreign References:
| US3002011A | 1961-09-26 | |||
| US2872458A | 1959-02-03 |
Other References:
JPN6014052541; 熊谷万平、春日和教: '３-（８一力ルボキシエチル）-１，２一ジチオラン誘導体の合成' 日本化学雑誌 第８４巻、第１２号, 1963, 第９８６-９８８
JPN6014052542; Ｒｉｃｈａｒｄ Ｃ． Ｔｈｏｍａｓ， ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ＤＬ-１，２-ｄｉｔｈｉｏｌａｎｅ-３-ｃａｐｒｏｉｃ ａｃｉｄ ａｎｄ ＤＬ-１，２-ｄｉｔｈｉｏｌａｎｅ-３-ｂｕｔｙｒｉｃ ａｃｉｄ， ｈｏｍｏｌｏｇｓ ｏｆ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．７８, 1956, ｐｐ．６１５１-６１５３
JPN6014052544; Ｑｕｅｎｔｉｎ Ｆ． Ｓｏｐｅｒ， ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｅｓ ｏｆ ＤＬ-alpha-ｌｉｐｏｉｃ ａｃｉｄ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．７６, 1954, ｐｐ．４１０９-４１１２
JPN6014052545; Ｌｅｓｔｅｒ Ｊ． Ｒｅｅｄ， ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｅｓ ｏｆ ＤＬ-alpha-ｌｉｐｏｉｃ ａｃｉｄ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．７７, 1955, ｐｐ．４１６-４１９
JPN6014052547; 中野勇: 'alpha-Ｌｉｐｏｉｃ Ａｃｉｄ及び其の類縁化合物の研究（第３報）' 薬学雑誌 Ｖｏｌ．７６, 1956, ｐｐ．９４７-９５０
JPN6014052542; Ｒｉｃｈａｒｄ Ｃ． Ｔｈｏｍａｓ， ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ＤＬ-１，２-ｄｉｔｈｉｏｌａｎｅ-３-ｃａｐｒｏｉｃ ａｃｉｄ ａｎｄ ＤＬ-１，２-ｄｉｔｈｉｏｌａｎｅ-３-ｂｕｔｙｒｉｃ ａｃｉｄ， ｈｏｍｏｌｏｇｓ ｏｆ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．７８, 1956, ｐｐ．６１５１-６１５３
JPN6014052544; Ｑｕｅｎｔｉｎ Ｆ． Ｓｏｐｅｒ， ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｅｓ ｏｆ ＤＬ-alpha-ｌｉｐｏｉｃ ａｃｉｄ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．７６, 1954, ｐｐ．４１０９-４１１２
JPN6014052545; Ｌｅｓｔｅｒ Ｊ． Ｒｅｅｄ， ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｅｓ ｏｆ ＤＬ-alpha-ｌｉｐｏｉｃ ａｃｉｄ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．７７, 1955, ｐｐ．４１６-４１９
JPN6014052547; 中野勇: 'alpha-Ｌｉｐｏｉｃ Ａｃｉｄ及び其の類縁化合物の研究（第３報）' 薬学雑誌 Ｖｏｌ．７６, 1956, ｐｐ．９４７-９５０
Attorney, Agent or Firm:
Kobayashi 浩
Norio Omori
Yasuhito Suzuki
Norio Omori
Yasuhito Suzuki
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