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Title:
LIPOSOME, FORMULATION CONTAINING LIPOSOME, AND METHOD FOR PRODUCING FORMULATION
Document Type and Number:
Japanese Patent JP2018199705
Kind Code:
A
Abstract:
To provide: liposomes used in producing pharmaceutical compositions used in treating or preventing symptoms including endometriosis, ischemic reperfusion injury, myocardial infarction, and restenosis substantially; and a method that can be used in mass production that is cost effective yet can control characteristics of a liposome formulation so as to produce liposomes that are substantially uniform and suitable for clinical use.SOLUTION: The invention provides the use of a liposome comprising a lipid ingredient and an encapsulated therapeutic agent, with a mass ratio of the therapeutic agent to the lipid of about 1:5 to 1:8, where the lipid ingredient comprises DSPC, DSPG and cholesterol in a molar ratio of about 3:1:2, the liposome has compressibility less than 0.70 ml/g, and the therapeutic agent is a bisphosphonate.SELECTED DRAWING: Figure 4

Inventors:
YORAM RICHTER
YEHUDA ZELIG
OMAR ELMALAK
DROR EYAL
Application Number:
JP2018160162A
Publication Date:
December 20, 2018
Filing Date:
August 29, 2018
Export Citation:
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Assignee:
BIOREST LTD
International Classes:
A61K9/127; A61K9/51; A61K31/663; A61K47/24; A61K47/28; A61P9/10; A61P29/00
Attorney, Agent or Firm:
特許業務法人 松原・村木国際特許事務所