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Title:
LIQUIRITIN DERIVATIVE AND EXTERNAL-USE MEDICINE FOR SKIN CONTAINING THE SAME COMPOUND
Document Type and Number:
Japanese Patent JPH05140181
Kind Code:
A
Abstract:

PURPOSE: To provide new liquiritin derivatives excellent in melanogenesis- inhibitory effect and water solubility, capable of, therefore, ready preparation and capable of effectively showing a whitening effect by blending it with a base of an external-use medicine for the skin.

CONSTITUTION: Compounds of formula I (n is 1 or 2), e.g. in the case of n=1, liquiritin-α-glucoside showing the following properties; Molecular weight: 580.54; Melting point: 161.3-166.9°C; Solubility: readily soluble in water, soluble in methanol and insoluble in ethanol; Elemental analysis (theoretical value) : C 55.86%, H 5.56%; Anthrone color reaction: positive, etc. The above-mentioned compound can be obtained, e.g. by dissolving liquiritin in 0.1 M acetate buffer solution (pH 5.5) containing 10% ethanol, subsequently acting an enzyme derived from Bacillus macerans IFO-3490 strain thereon in the presence of dextrin and calcium chloride, then deactivating the enzyme, subsequently acting α-amylase thereon and purifying the reaction mixture.


Inventors:
SAEGUSA TAKAHIRO
Application Number:
JP1991000300847
Publication Date:
June 08, 1993
Filing Date:
November 15, 1991
Export Citation:
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Assignee:
SANSHO SEIYAKU KK
International Classes:
A61K8/60; A61K8/00; A61K8/02; A61K8/06; A61K9/06; A61K9/12; A61K9/70; A61K31/70; A61K31/7028; A61K31/7034; A61K31/7048; A61P17/00; A61P43/00; A61Q19/02; C07H15/203; C07H15/26; (IPC1-7): A61K7/00; A61K31/70; C07H15/203