Title:
肝癌治療剤
Document Type and Number:
Japanese Patent JP5306327
Kind Code:
B2
Abstract:
A novel pharmaceutical composition for treating or preventing hepatocellular carcinoma and a method of treatment are provided. A pharmaceutical composition for treating or preventing liver cancer is obtained by combining a chemotherapeutic agent with an anti-glypican 3 antibody. Also disclosed is a pharmaceutical composition for treating or preventing liver cancer which comprises as an active ingredient an anti-glypican 3 antibody for use in combination with a chemotherapeutic agent, or which comprises as an active ingredient a chemotherapeutic agent for use in combination with an anti-glypican 3 antibody. Using the chemotherapeutic agent and the anti-glypican 3 antibody in combination yields better therapeutic effects than using the chemotherapeutic agent alone, and mitigates side effects that arise from liver cancer treatment with the chemotherapeutic agent.
Inventors:
Kyoko Kinoshita
Masamichi Sugimoto
Takahiro Ishiguro
Masamichi Sugimoto
Takahiro Ishiguro
Application Number:
JP2010505322A
Publication Date:
October 02, 2013
Filing Date:
March 19, 2009
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
A61K39/395; A61K31/435; A61P35/00; A61P43/00; C07K16/28
Foreign References:
| WO2007053573A1 | ||||
| WO2007091622A1 | ||||
| WO2006006693A1 | ||||
| WO2006046751A1 | ||||
| WO2006067913A1 | ||||
| WO2003000883A1 | ||||
| WO2007099988A1 |
Other References:
池田公史他,原発性肝がんの薬物療法とキナーゼ阻害剤sorafenib,血液・腫瘍科,日本,科学評論社,2008年1月28日,Vol.56,No.1,p.70-75
Attorney, Agent or Firm:
Seiji Ohno
Koji Morita
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Natsuki Ito
Koji Morita
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Natsuki Ito