To provide a locating and clamping device capable of holding a preliminarily held position without changing the orientation of a work panel before clamping.

The locating and clamping device configures its clamp arm drive means for moving a clamp arm 6 by connecting two drive cylinders 16, 17; wherein a first piston 18 of one drive cylinder 16 moves the clamp arm 6 to an unclamp position and a clamp position, and a second piston 22 of the other drive cylinder 17 comes into contact with the first piston 18 to determine and hold the temporarily holding position of the clamp arm 6.