Title:
LONG-ACTING HUMAN FOLLICLE-STIMULATING HORMONE FORMULATION USING IMMUNOGLOBULIN FRAGMENT
Document Type and Number:
Japanese Patent JP2015212265
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a long-acting human follicle-stimulating hormone formulation having an effect which relatively highly maintains in vivo activity of human follicle-stimulating hormone, and remarkably prolongs the half-life in blood, and having improved in vivo duration and stability comprising a human follicle-stimulating hormone conjugate; and to provide a preparation method thereof.SOLUTION: A long-acting human follicle-stimulating hormone formulation having improved in vivo duration and stability comprises a human follicle-stimulating hormone conjugate that is prepared by linking human follicle-stimulating hormone with an immunoglobulin Fc region via a non-peptidyl polymer selected from polyethylene glycol, polypropylene glycol, copolymers of ethylene glycol and propylene glycol, polyoxyethylated polyols, polyvinyl alcohol, polysaccharides, dextran, polyvinyl ethyl ether, biodegradable polymers, lipid polymers, chitins, hyaluronic acid, and combinations thereof.
Inventors:
KIM CHAN FAN
HONG SUNG KAP
LEE BYUNG SUN
KWAK SOO YOUNG
LEE MI JI
CHOI IN YOUNG
KWON SE CHANG
HONG SUNG KAP
LEE BYUNG SUN
KWAK SOO YOUNG
LEE MI JI
CHOI IN YOUNG
KWON SE CHANG
Application Number:
JP2015107926A
Publication Date:
November 26, 2015
Filing Date:
May 27, 2015
Export Citation:
Assignee:
HANMI SCIENCE CO LTD
International Classes:
A61K38/24; A61K47/32; A61K47/34; A61K47/36; A61K47/42; A61K47/48; A61P15/08; C07K19/00
Domestic Patent References:
| JP2007536211A | 2007-12-13 |
Foreign References:
| WO2009098318A1 | 2009-08-13 |
Attorney, Agent or Firm:
Patent business corporation glory patent office