To provide an injectable composition for determining suitable complexing agents and more favorable co-solvents to alleviate the shortcomings of prior art oxytetracycline compositions having exhibited relatively high viscosity at low temperatures which makes injection difficult, have shown poor stability and suffered limitations on concentration of active components.
An injectable composition of higher residual effect with reduced detrimental effects such as pain at injection site, swelling, tissue irritancy or necrosis and containing as active component a tetracycline compound, either as the free base or a salt thereof with a physiologically acceptable acid, complexed with a substantially equimolar amount of a magnesium compound, is solubilized in a water-miscible solvent system comprising, either (i) (a) glycerol formal in an amount of from about 10 to about 50% v/v; with (b) polyethylene glycol in an amount of from about 1 to 15% v/v; or (ii) from about 25 to about 75% v/v of N-methylpyrrolidone, the composition optionally containing a pH modifier in an amount sufficient to maintain a physiologically acceptable pH, the balance being made up with an adequate amount of water.
COPYRIGHT: (C)2008,JPO&INPIT
HOLMES DREW
| JPS55143910A | 1980-11-10 | |||
| JPS4935410B1 | 1974-09-21 |
| US5075295A | 1991-12-24 | |||
| GB1250304B |
Kakehi Yuro
Takeshi Ohara
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