Title:
長時間放出性の口腔生物接着性錠剤
Document Type and Number:
Japanese Patent JP5411398
Kind Code:
B2
Abstract:
A bioadhesive tablet wherein the active ingredient may be protected from water or the surrounding environment, thereby protecting it from metabolism or from other degradation caused by moisture, enzymes, or pH effects, and making it bioavailable only at a controlled rate. The active ingredient may be protected from moisture during the manufacturing process and more importantly may be protected from moisture and the immediate septic environment until after the patient has applied the tablet, and then only at a slow and controlled rate. It is by this process of progressive hydration that the active ingredient remains protected for many hours after administration. It is also by the process of progressive hydration that controlled and sustained release is achieved because only that part of the active ingredient that is the hydrated (aqueous) fraction of the tablet is available for absorption (bioavailable).
Inventors:
William Jay Bologna
Howard El Levine
Philip Cartier
Dominique de Ziegler
Howard El Levine
Philip Cartier
Dominique de Ziegler
Application Number:
JP2000565858A
Publication Date:
February 12, 2014
Filing Date:
August 24, 1999
Export Citation:
Assignee:
Columbia Laboratories (Bermuda) Limited
International Classes:
A61K9/22; A61K9/00; A61K31/568; A61K47/02; A61K47/12; A61K47/26; A61K47/30; A61K47/32; A61K47/36; A61K47/38; A61K47/48; A61P5/26; A61P9/00; A61P9/10; A61P11/06; A61P15/10; A61P19/10; A61P25/28; A61K9/20
Domestic Patent References:
| JP9506092A | ||||
| JP60215622A | ||||
| JP4502913A | ||||
| JP4227911A | ||||
| JP6100467A |
Foreign References:
| US5723143 |
Other References:
Drug Development and Industrial Pharmacy,1988年,Vol.14,Issue 2&3,p.283-318
Pharmaceutical Research,1996年,Vol.13,No.8,p.1228-1232
Pharmaceutical Research,1996年,Vol.13,No.8,p.1228-1232
Attorney, Agent or Firm:
Aoyama Aoi
Satoshi Hashimoto
Takuji Yamada
Michiko Matsutani
Sakurai Yoko
Satoshi Hashimoto
Takuji Yamada
Michiko Matsutani
Sakurai Yoko