Title:
Low allergy-inductive chimera protein belonging to the lipid transfer protein family of a wall nettle (Parietariajudaica) used for allergy medical treatment
Document Type and Number:
Japanese Patent JP6148088
Kind Code:
B2
Abstract:
Hypoallergenic chimeric proteins belonging to the lipid transfer family of Parietaria judaica for use in the treatment of allergies. The present invention relates to recombinant DNA molecules which encode chimeric polypeptides of differing allergens of Parietaria judaica which can be used for the prevention and treatment of allergies, in particular pollen allergies. Specifically, chimeric polypeptides composed of fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics are described. Methods for producing these recombinant polypeptides in heterologous expression systems are also described. Efficient methods of purifying the chimeric proteins are also described.
Inventors:
Asturias Ortega, Euan Andres
Martinez Galate, Alberto
Gonzales Rioya, Roberto
Martinez Galate, Alberto
Gonzales Rioya, Roberto
Application Number:
JP2013141864A
Publication Date:
June 14, 2017
Filing Date:
July 05, 2013
Export Citation:
Assignee:
Vial Industrial Pharmacutica, S.A.
International Classes:
C12N15/09; A61K38/00; A61K39/00; A61K39/36; A61P37/02; A61P37/08; C07K14/415; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Foreign References:
| WO2005085278A1 | ||||
| WO2004104047A1 |
Attorney, Agent or Firm:
Okabe
Shinichi Usui
Norimichi Takanashi
Tsuneo Kobayashi
Masami Saito
Katsuhiko Kimura
Honda Aki
Shinichi Usui
Norimichi Takanashi
Tsuneo Kobayashi
Masami Saito
Katsuhiko Kimura
Honda Aki