Title:
核酸伝達用低密度リポタンパク質類似(LDL-like)陽イオン性ナノ粒子、その製造方法、及びこれを用いた核酸の伝達方法
Document Type and Number:
Japanese Patent JP5336500
Kind Code:
B2
Abstract:
Disclosed are a LDL-like cationic nanoparticle for delivering a nucleic acid gene with improved transfection efficiency and stability, which is surface modified and re-constructed by mimicking lipid components of a natural LDL, a method for preparation of the same, and a method for delivering nucleic acid genes using the same. The cationic nanoparticle of the present invention could effectively be applied in treatment of cancer that overexpress LDL receptors.
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Inventors:
Park, Tae Gwang
Kim, Hyunryung
Kim, inkyun
Kim, Hyunryung
Kim, inkyun
Application Number:
JP2010529879A
Publication Date:
November 06, 2013
Filing Date:
October 17, 2008
Export Citation:
Assignee:
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
International Classes:
A61K47/28; A61K9/51; A61K31/7105; A61K47/14; A61K47/18; A61K47/24; A61K47/42; A61K47/48; A61K48/00
Domestic Patent References:
| JP2001503735A |
Other References:
LIU,F. et al,Emulsion formulations as a vector for gene delivery in vitro and in vivo,Advanced Drug Delivery Reviews,1997年,Vol.24, No.2-3,p.265-271
Attorney, Agent or Firm:
Ryu Iwatani
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