Title:
1α,25-ジヒドロキシビタミンD3の低血漿カルシウム上昇性16,23-ジエン-25-オキシムアナログ
Document Type and Number:
Japanese Patent JP5449767
Kind Code:
B2
Abstract:
The present invention provides novel 16,23-diene 25-oxime ether analogs of 1,25-dihydroxy vitamin D3, compositions comprising these compounds and methods of using these compounds as inhibitors of CYP24. In particular, the novel compound of the invention are useful for treating diseases which benefit from a modulation of the levels of 1,25-dihydroxy vitamin D3, for example, cell-proliferative disorders.
Inventors:
Uttam Saha
Gary H. Posner
Mehmat Carlaman
Gary H. Posner
Mehmat Carlaman
Application Number:
JP2008508035A
Publication Date:
March 19, 2014
Filing Date:
April 25, 2006
Export Citation:
Assignee:
Sight Chroma Inc.
Johns Hopkins University
Johns Hopkins University
International Classes:
C07C401/00; A61K31/593; A61K45/00; A61P3/02; A61P5/14; A61P5/16; A61P17/00; A61P17/02; A61P17/06; A61P19/08; A61P19/10; A61P35/00; A61P35/02; A61P37/00; A61P37/06; A61P43/00
Domestic Patent References:
| JP2009861A | ||||
| JP7188159A | ||||
| JP10045713A | ||||
| JP2005536444A | ||||
| JP2007506765A | ||||
| JP2001503403A |
Foreign References:
| WO2003031400A1 | ||||
| WO2005030222A1 |
Other References:
POSNER,G.H. et al,Conceptually New Low-Calcemic Oxime Analogues of the Hormone 1α,25-Dihydroxyvitamin D3: Synthesis and Biological Testing,Journal of Medicinal Chemistry,2002年,Vol.45, No.8,p.1723-1730
CHEN,T.C. et al,An evaluation of 1,25-dihydroxyvitamin D3 analogs on the proliferation and differentiation of cultured human keratinocytes, calcium metabolism and the differentiation of human HL-60 cells,Journal of Nutritional Biochemistry,1993年,Vol.4, No.1,p.49-57
CLARK,J.W. et al,Effects of analogs of 1,25(OH)2 vitamin D3 on the proliferation and differentiation of the human chronic myelogenous leukemia cell line, RWLeu-4,Journal of Cancer Research and Clinical Oncology,1992年,Vol.118, No.3,p.190-4
BISCHOF,M.G. et al,Growth inhibitory effects on human colon adenocarcinoma-derived Caco-2 cells and calcemic potential of 1α,25-dihydroxyvitamin D3 analogs: structure-function relationships,Journal of Pharmacology and Experimental Therapeutics,1995年,Vol.275, No.3,p.1254-60
CHEN,T.C. et al,An evaluation of 1,25-dihydroxyvitamin D3 analogs on the proliferation and differentiation of cultured human keratinocytes, calcium metabolism and the differentiation of human HL-60 cells,Journal of Nutritional Biochemistry,1993年,Vol.4, No.1,p.49-57
CLARK,J.W. et al,Effects of analogs of 1,25(OH)2 vitamin D3 on the proliferation and differentiation of the human chronic myelogenous leukemia cell line, RWLeu-4,Journal of Cancer Research and Clinical Oncology,1992年,Vol.118, No.3,p.190-4
BISCHOF,M.G. et al,Growth inhibitory effects on human colon adenocarcinoma-derived Caco-2 cells and calcemic potential of 1α,25-dihydroxyvitamin D3 analogs: structure-function relationships,Journal of Pharmacology and Experimental Therapeutics,1995年,Vol.275, No.3,p.1254-60
Attorney, Agent or Firm:
Axis International Patent Business Corporation