Title:
ルブリシン局在軟骨様組織、その製造方法及びそれを含む関節軟骨損傷治療用組成物
Document Type and Number:
Japanese Patent JP7224001
Kind Code:
B2
Abstract:
The present invention provides: a lubricin-localized cartilage-like tissue characterized in that, when in an arbitrary cross section passing a first center of mass of a cartilage-like tissue derived from pluripotent stem cells or a center-of-mass region, which is a portion inside a concentric sphere being centered at the first center of mass and having a diameter of [first major diameter × 0.2], the expression level of lubricin per unit area contained in a central region, which is a portion inside a concentric circle being centered at a second center of mass that is the center of mass of the cross section and having a diameter of [major diameter of cross section (second major diameter) × (0.4 to 0.9) ] is referred to as the central lubricin level and the expression level of lubricin per unit area contained in the non-central region is referred to as the non-central lubricin level, the ratio of [non-central lubricin level/central lubricin level] is greater than 1 and, therefore, lubricin is localized therein; and a method for producing the lubricin-localized cartilage-like tissue. Further, the present invention provides a composition for treating articular cartilage damage which comprises the lubricin-localized cartilage-like tissue.
Inventors:
Noriyuki Tsumaki
Yoshiaki Takei
Yoshiaki Takei
Application Number:
JP2020561552A
Publication Date:
February 17, 2023
Filing Date:
December 20, 2019
Export Citation:
Assignee:
Kyoto University
ASAHI KASEI KABUSHIKI KAISHA
ASAHI KASEI KABUSHIKI KAISHA
International Classes:
C12N5/077; C12N5/0735
Foreign References:
| WO2016133208A1 |
Other References:
WU, X. et al.,Mol Biotechnol, (2013), Vol.54, pp.331-336
YU, B. et al.,Biochem Biophys Res Communm (2011), Vol.414, pp.412-418
WANG, T. et al.,J Biomed Mater Res, (2009), Vol.88A, pp.935-946
CANDRIAN, C. et al.,Arthrits & Rheumatism, (2008), Vol.58, No.1, pp.197-208
GRAD, S. et al.,Biorheology, (2006), Vol.43, pp.259-269
LUO, L. et al.,J Tissue Eng Regen Med, (2017), Vol.11, pp.2613-2628
YU, B. et al.,Biochem Biophys Res Communm (2011), Vol.414, pp.412-418
WANG, T. et al.,J Biomed Mater Res, (2009), Vol.88A, pp.935-946
CANDRIAN, C. et al.,Arthrits & Rheumatism, (2008), Vol.58, No.1, pp.197-208
GRAD, S. et al.,Biorheology, (2006), Vol.43, pp.259-269
LUO, L. et al.,J Tissue Eng Regen Med, (2017), Vol.11, pp.2613-2628
Attorney, Agent or Firm:
Aoki Atsushi
Shinji Mihashi
Kazuhiro Nakamura
Saito Tsuko
Shunsuke Sanma
Junji Shibata
Shinji Mihashi
Kazuhiro Nakamura
Saito Tsuko
Shunsuke Sanma
Junji Shibata
Previous Patent: LIQUID MATERIAL SUPPLY DEVICE AND LIQUID MATERIAL SUPPLY METHOD
Next Patent: PRODUCTION OF FATTY ACID LOWER ALKYL ESTERS
Next Patent: PRODUCTION OF FATTY ACID LOWER ALKYL ESTERS