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Title:
発光性トランスジェニック非ヒト動物、子孫、派生細胞(cellderivatives)およびそれらの使用
Document Type and Number:
Japanese Patent JP2009523024
Kind Code:
A
Abstract:
It is described a stable recombinant stem cell able to express an apophotoprotein and produce a bioluminescent signal in the presence of a suitable chromophore as substrate in response to intracellular calcium concentration variation: methods for identifying agents modulating the differentiation of stem cells towards a specific cell lineage; methods for identifying a ligand able to stimulate a specific cell lineage target; methods for identifying an antagonist to ligand known to stimulate a specific cell lineage target uses of stable recombinant stem cells for in vitro testing of toxicity and/teratology of a substance.

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Inventors:
Sylvia Cainarka
Sintia Nucci
Sabrina Colazza
Stephan romee
Application Number:
JP2008549993A
Publication Date:
June 18, 2009
Filing Date:
January 10, 2007
Export Citation:
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Assignee:
Ikusu Ikuename Esse Pi A
International Classes:
C12N5/10; A01K67/027; C12N15/09; C12Q1/02; G01N21/76; G01N33/483; G01N37/00
Domestic Patent References:
JP2000308490A2000-11-07
Foreign References:
WO2006094805A12006-09-14
EP1700865A12006-09-13
WO2001033957A12001-05-17
WO2000028025A12000-05-18
EP1413584A12004-04-28
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro



 
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