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Title:
LYOPHILIZATES HAVING IMPROVED RECONSTITUTABILITY
Document Type and Number:
Japanese Patent JP2010264249
Kind Code:
A
Abstract:

To provide lyophilizates having an improved dissolution rate and reconstitutability, a process for their preparation, and reconstitution in a particle-free manner.

Corresponding solutions already filled for lyophilization, which have, if necessary, previously been warmed in order to accelerate dissolution of the substance, filtered-optionally sterile-filtered-and filled, are rewarmed to from 30°C to 95°C directly in the vials in the freeze drier, and the freezing phase is then carried out rapidly from this elevated temperature to the desired low freeze-drying temperature.

COPYRIGHT: (C)2011,JPO&INPIT


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Inventors:
KURZ THEKLA
KRUEGER LUDWIG
HESSE BRIGITTE
KARNATZ ARND
Application Number:
JP2010126408A
Publication Date:
November 25, 2010
Filing Date:
June 02, 2010
Export Citation:
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Assignee:
MERCK PATENT GMBH
International Classes:
A61J3/00; A61K9/19; A61K31/155; A61K31/165; A61K31/40; A61K31/402; A61P9/00; A61P9/10; A61P43/00; F26B5/06
Domestic Patent References:
JPH07252144A1995-10-03
JPH02115030A1990-04-27
JPH0733793A1995-02-03
JPH09183729A1997-07-15
Foreign References:
DE4430861A11996-03-07
EP0758644A11997-02-19
EP0589336A11994-03-30
Attorney, Agent or Firm:
Kiyoji Kuzuwa



 
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